Links

Reaction Info

Info on reactions (inc. named items), electron pushing, acid/base catalysis, natural pdt. syntheses

• Acronyms (Hans Reich's Collection - DOC)
• Carbonyl Chemistry (Hans Reich's Collection - DOC)
• Electron Pushing/Drawing Mechanisms (Hans Reich's Collection - DOC)
• Total Syntheses Indexed by Named Reactions (Hans Reich's Collection - DOC): set of ~700 total synthesis schemes indexed by named reactions
• Named Reagents (Hans Reich's Collection - DOC)
• Named Rules and Effects (Hans Reich's Collection - DOC)
• Organic Reactions
• Organic Syntheses
• Protecting Groups-Organic Chemistry Portal
• Terms used in Physical Organic Chemistry

• Reaction Topics

  • Acidity and Basicity (Prof. William Reusch, Michigan State University)
  • Combinatorial Chemistry Review
  • Combinatorial Chemistry (at Science Direct)
  • Flow Chemistry-Organic Chemistry Portal
  • Green Chemistry
  • Green Chemistry-Organic Chemistry Portal
  • Microwave Syntheses-Organic Chemistry
  • Multicomponent Reactions-Organic Chemistry
  • Organoboron Chemistry
  • Organocatalysis-Organic Chemistry
  • Organometallic Chemistry (Hans Reich's Collection - DOC)
  • Pericyclic Reactions (Hans Reich's Collection - DOC)
  • Photochemistry (Prof. William Reusch, Michigan State University)
  • Reduction and Oxidation (Hans Reich's Collection - DOC)
  • Sonochemistry-Organic Chemistry

• Other Sites on Named Reactions

  • Name Reaction.com (Toronto, by Endri Gjiri)
  • Named Reactions-Organic Chemistry Portal (by Doug Taber)
  • Organic Reactions (Wikipedia)
  • SynArchive.com (by Daniel Beaudoin)
  • Monomerchem, Inc. (by Marcus Brackeen)
  • "ReactionFlash™ App" (developed by Elsevier and Prof.Erick M.Carreira, ETH-Zürich): over 1000 named reactions, their mechanisms and examples published in peer-reviewed literature
  • ReactionGuessr: a guess named reaction game, developed by Vincent Le Fouler

• Lists of Total Syntheses (Reaction Schemes are included)

  • Natural Product Syntheses (Hans Reich's Collection - DOC)
  • Totally Synthetic Blog (by Docherty/Taber)
  • SynArchive
  • Total Synthesis of Natural Products Dojo
  • Prof. Dirk Trauner (New York University) group's Total syntheses problem sets
  • "Synthesis Club Roadmap Problems" by German Cancer Research Center
  • "Synthesis Workshop" by Dr. Matthew Horwitz: an open access video podcast, including four complementary modules - Total Synthesis, Named Reactions, Research Spotlights, and Culture of Chemistry

Chemical Data

Info on pKa values, nucleophile/electrophiles, A-values, solvents, physical constants, etc.

• A-Values (Hans Reich's Collection - DOC)
• Bond Energies and Bond Dissociation Energies (Prof. William Reusch, Michigan State University)
• Bond Dissociation Energies (Prof. Armen Zakarian, University of California Santa Barbara)
• Bond Dissociation Energy Estimator by the National Renewable Energy Laboratory (NREL)
• Electronegativities of Elements-Periodic Table (Hans Reich's Collection - DOC)
• Organoboron Chemistry
• pKa Values (Water, DMSO, gas phase) (Hans Reich's Collection - DOC)
• Properties of Common Organic Compounds (Steven Murov)

• Nucleophile/Electrophile Reactivity

  • Database of Nucleophilicities and Electrophilicities
  • Mayr's Reactivity Scales Poster 2020
  • Mayr's Reactivity Scales Poster 2016
  • Reactivity Scales for Organocatalytic Reactions Poster

• Solvents

  • Solvent Properties Table
  • Solvent Miscibility Table
  • Solvent Strength Calculation
  • Solvent Strength Calculation (see pages 8-15)
  • Green Chromatography Solvent Selection Tables (Green Chem., 2012,14, 3020; Supplementary Data)
  • See the DOC Green Chemistry Page

• Periodic Tables

  • Web Elements (interactive)
  • PTable (interactive)
  • PTable (PDF)
  • IUPAC
  • IUPAC (PDF)
  • American Elements (interactive)
  • Chemicool (interactive)
  • Elements Database (interactive)
  • Chemiplus (interactive)
  • Resources on Periodic Table (Steven Murov)
• Photophysical Properties of Photosensitizers and Quenchers (Steven Murov)
• Physical Constants
• Physical Constants wall chart (NIST)
• SI Units
• Nomograph (Boiling point vs Pressure, Aldrich)
• Data Conversion
• Math Formulas
• Frequency - Wavelength - Energy Converter (Prof. William Reusch, Michigan State University)
• Chemistry Data Tables (Wired Chemist)

Spectroscopy Resources

Info on: NMR (1H, 13C, 19F 31P, 11B, 77Se), IR, UV, MS spectroscopy and links to spectra databases

• General

  • Spectroscopy (Prof. William Reusch, Michigan State University)
  • Spectroscopy Lectures-Nowick (UCI)

• General NMR

  • NMR Spectroscopy (Hans Reich's Collection - DOC)
  • NMR Spectroscopy (Prof. William Reusch, Michigan State University)
  • NMR Supplemental NMR Topics (Prof. William Reusch, Michigan State University)
  • The Basics of NMR-Hornak (Rochester Institute of Technology)
  • NMR Dictionary
  • NMR Multiplet Guide-Nowick (UCI)
  • Dr. Glenn Facey (University of Ottawa) NMR blogs

• NMR Data

  • ¹H NMR Shifts (Hans Reich's Collection - DOC)
  • ¹³C NMR Shifts (Hans Reich's Collection - DOC)
  • Coupling: J_(H–H) (Hans Reich's Collection - DOC)
  • Coupling: J_(C–C) and J_(C–H) (Hans Reich's Collection - DOC)
  • NMR Solvents (Hans Reich's Collection - DOC)
  • NMR Trace Impurities

• Multinuclear NMR Data

  • ¹⁹F NMR Shift (Hans Reich's Collection - DOC)
  • ¹⁹F NMR Coupling Constant (Hans Reich's Collection - DOC)
  • ³¹P NMR Shift (Hans Reich's Collection - DOC)
  • ³¹P NMR Coupling Constant (Hans Reich's Collection - DOC)
  • ¹¹B
  • ⁷⁷Se NMR Shift (Hans Reich's Collection - DOC)
  • NMR Periodic Table

• Mass Spectroscopy

  • MS Spectroscopy (Prof. William Reusch, Michigan State University)
  • Exact Masses & Isotope Abundance Ratios and Calculators (Prof. William Reusch, Michigan State University)

• UV Spectroscopy

  • UV Spectroscopy (Prof. William Reusch, Michigan State University)

• IR Spectroscopy

  • IR Spectroscopy (Prof. William Reusch, Michigan State University)
  • IR Problems (Prof. William Reusch, Michigan State University)
  • IR Problems/Training (Colby College)

• Databases of Spectra

  • Spectral Database for Organic Compounds
  • NMRShiftDB (database of spectra and tools to predict spectra)
  • Polymer Science Learning Center Spectral Database
  • ChemSpider

• Problems

  • NMRShiftDB Problem of the Month, Archive
  • NMR Spectral Problems (UCLA)
  • Spectral Zoo Problems
  • 20 Problems (CU Boulder)
  • 64 Problems (Notre Dame)
  • Spectroscopy Exams-Nowick (UCI)
  • NMR Problems - Rainer Haeßner (www.nmr.tips): Sets of NMR problems and with interactive walk-through solutions. An overview of all problems can be viewed on this page

Organic Compound Info

Info on naming organic compounds, functional groups, assigning R/S. and organic compound types

• Nomenclature

  • General Information (Hans Reich's Collection - DOC)
  • Functional Groups Summary (Hans Reich's Collection - DOC)
  • Named Reagents (Hans Reich's Collection - DOC)
  • Reactive Intermediates (Hans Reich's Collection - DOC)
  • Acronyms (Hans Reich's Collection - DOC)
  • Nitrogen Containing Functional Groups Summary (Hans Reich's Collection - DOC)
  • Abbreviations: Journal of Organic Chemistry
  • IUPAC (ACDLabs)
  • RSC IUPAC Rules (RSC, free registration required)
  • IUPAC Compendium of Chemical Terminology (the Gold Book)
  • IUPAC Glossary of Class Names of Organic Compounds and Reactive Intermediates 1995
  • Numbering of Ring Systems

• Stereochemistry

  • Chiral Configurations (Prof. William Reusch, Michigan State University)
  • IUPAC Rules for the Nomenclature of Organic Chemistry, Section E: Stereochemistry(1974)
  • Axial chirality-Wikipedia
  • Chirality and Odour Perception

• Organometallic Topics

  • Organolithium Reagents (Hans Reich's Collection - DOC)
  • Organometallic Chemistry General (Prof. William Reusch, Michigan State University)
  • Organometallic Hypertextbook

• Organic Compound Special Types

  • Heterocyclic Chemistry (Prof. William Reusch, Michigan State University)
  • Nitrogen Containing Functional Groups Summary (Hans Reich's Collection - DOC)
  • Pesticides
  • Polymers (Prof. William Reusch, Michigan State University)
  • Carbohydrates (Prof. William Reusch, Michigan State University)
  • Proteins and Amino Acids (Prof. William Reusch, Michigan State University)
  • Nucleic Acids (Prof. William Reusch, Michigan State University)
  • Steroids
  • Sweeteners
  • Aroma Compounds-Wikipedia

• Databases

  • CAS Source Index (CASSI) Search Tool
  • Beyond CASSI
  • ChEMBL (RSC): manually curated databases of bioactive molecules with drug-like properties (~6900 compounds, ~9800 bioactivities)
  • Chemical Abstract Service (CAS)
  • ChemSpider (RSC)
  • ChemSynthesis
  • eMolecules (suppliers)
  • OSIRIS Property Explorer
  • PubChem (NIH)
  • RCSB Protein Databank
  • Reaxys
  • Science of Synthesis
  • Unichem
  • WolframAlpha: Chemistry

• Sites on Some General Info on Organic Compounds

  • Compound Interest (infographics on various topics)
  • Disease Focused Posters-Jón Njarðarson (Arizona)
  • Top 200 Pharmaceuticals Posters-Jón Njarðarson (Arizona)
  • Molecules with Silly or Unusual Names
  • Molecules that Matter
  • Molecule of the Month

Safety Resources

Links to useful resources for safe operations of organic chemistry laboratories

• Dow Lab Safety Academy
• Lab Safety Institute
• OSHA Occupational Chemistry Database
• Prudent Practices in the Laboratory (Free download, PDF)
• UCLA: Health & Safety
• UC San Diego-Lab Safety Video Links
• Safety Data Sheet (SDS) lookup by ChemInfo: SDS quick lookup by brand, catalog number, or CAS number from Acros, Maybridge, Fisher, TCI, Fluorochem
• Safety Data Sheet (SDS) lookup by ChemicalSafety
• Lab Treatment of Waste Chemicals
• Stability of Diazo Compounds and Diazo Transfer Reagents

Chemical Societies and Portals

Links to chemical societies especially those that have a focus on or related to organic chemistry

• American Association for the Advancement of Science
• American Chemical Society
• American Chemical Society, Division of Organic Chemistry
• Canadian Society for Chemistry, Organic Division
• Chemical Institute of Canada
• International Isotope Society
• International Society of Heterocyclic Chemistry
• National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChe)
• North American Catalysis Society
• Royal Society of Chemistry-Organic Division
• The Society of Synthetic Organic Chemistry, Japan
• The World Association of Theoretical and Computational Chemists
• The American Association of Pharmaceutical Scientists

Literature Sources

Links to literature resources (i.e. lists of journals with an organic chemistry focus)

• ACS Organic Division's Links to Organic Journals
• Organic Reactions
• Organic Syntheses
• ACS Online Publications
• The Goodman's Group List-University of Cambridge
• Reference Resolver

Laboratory Techniques

Links to resources for doing various general laboratory procedures in organic chemistry labs

• Not Voodoo Organic Techniques/Information
• NOP General Techniques
• NOP all Experiments
• ChemSpider Synthetic Procedure Pages
• Organic Syntheses
• "The Schlenk Line Survival Guide" by Dr. Andryj Borys
• Working with Nitrogen Line: the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
• Titration of Organolithium: compiled by Emslie group (McMaster University), hosted by the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
• Transfer of Chemicals Using Syringes: the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
• Cooling Baths: compiled by the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
• TLC Stains
• Solvent Degassing
• Solvent Degassing by Freeze-Pump-Thaw: the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland
• Gas Handling: the Waser group at EPFL, the Swiss Federal Institute of Technology in Lausanne, Switzerland

Useful Software

Links to software applications that are likely useful for a broad selection of organic chemists

• Chemical Drawing Programs

  • ChemBioDraw

  • ChemBioDraw Tutorial Videos by Pierre Morieux

    • Colorful ChemDraw Collections
    • ChemDraw Magic 4: How to REALLY use ChemDraw 17, Using Hotkeys
    • ChemDraw Magic Tricks: Quick Catalytic Cycles
    • ChemDraw Magic 3: Dendrimers, Delivered
    • ChemDraw Magic 2
    • ChemDraw Magic 1
    • All Videos by Pierre Morieux
  • ChemDoodle
  • MarvinSketch: Structure Drawing Software

• Computational Chemistry

  • AMSOL
  • Wavefunction: Spartan

• Chemical Inventory and/or Electronic Lab Notebook (ELN)

  • "Open Enventory": free, open-source chemical inventory & ELN

    • User Guides
    • Original Software by Dr. Felix Rudolphi
    • Modified Version by Dr. Khoi Van: Dr. Khoi Van added some extra functions as well as some modification for U.S.-based users. Used by Texas A&M University, labs at Baylor University, labs at MIT.
  • "Sciformation" by Dr. Felix Rudolphi: Paid software for ELN, Inventory, LIMS, with broader applications beyond chemistry
  • "LabCup": Paid software for Chemical Inventory and Laboratory Management

• Diagram Drawing Programs

  • Chemix: online editor for drawing science lab diagrams and school experiment apparatus.
  • Biorender: online editor for drawing science diagrams with a library of life science related icons.

• Others

  • Awesome Cheminformatics: A curated list of Cheminformatics software, resources, and libraries.
  • Awesome Python Chemistry: A curated list of Python frameworks, libraries, software and resources related to Chemistry
  • Cheminfo.org: variety of tools for cheminformatics, including but not limited to: SDS lookup, search by exact mass in Pubchem, Wikipedia Chemical view, etc.
  • Search by exact mass in Pubchem: Search Pubchem database for compounds using provided exact mass
  • Chemcalc.org: collection of mass calculators: molecular formula to exact mass; mass to prediction of molecular formula; proteins/polymer mass distributions analyses; Mass spec exercises
  • MaxBridge
  • Schrödinger
  • Splotch.io: mobile app for organizing and annotating TLC data.
  • Vogel Scientific Software: CIARA and CALACO.

Resources for Educators and Students

Links and resources for educators and students in teaching and learning organic chemistry

• Virtual Textbook of Organic Chemistry (Prof. William Reusch, Michigan State University)
• Acronyms (Hans Reich's Collection - DOC)
• ChemTube (3D Organic Chemistry Animations)
• Chemistry by Design-Jón Njarðarson (Arizona)
• Chemical Educational Xchange (by JCE)
• Chimie générale & organiqué-Gérard Dupuis
• Organic Chemistry InfoGraphics-Roman Valiulin
• Determining the product of Substitution or Elimination Reactions-Robert Grossman (Kentucky)
• Drawing Substitution and Elimination Products-Robert Grossman (Kentucky)
• Electron Pushing/Drawing Mechanisms (Hans Reich's Collection - DOC)
• Organic Education Resources (OrganicERs.org cCWCS)
• Polymer Education Guide
• R/S Chemistry-Master Assigning Absolute Stereochemistry-Neil Garg
• Stereochemistry Help-Robert Grossman (Kentucky)
• The Golden Rules of Organic Chemistry
• The Organic Coloring Book by Neil Garg
• The Adult Organic Coloring Book by Neil Garg
• Chemistry Hall
• QR Chem (presentation materials for instructors)-Neil Garg
• MolSSI Education Resources: Free online tutorial materials including Programming, Software Development, and Computational Molecular Science.

• Lecture Notes

  • "Advanced Organic Chemistry", Prof. David Evans (Harvard): Chem 206 course notes
  • "Advanced Organic Chemistry", Eugene Kwan (Harvard): A set of reinterpretation of the Chem 206 course notes created by Professor David A. Evans
  • Heterocyclic Chemistry" (Prof. Phil Baran, The Scripps Research Institute): Also see Organic Chemistry Videos section for videos.
  • "NMR Spectroscopy" (Hans Reich's Collection - DOC): Chem 605 course
  • "Organic Synthesis", Prof. Andrew Myers (Harvard): Chemistry 115 Handouts, created as part of an advanced course on the synthesis of complex molecules
  • Open Source Lecture Notes-Bode Research Group (ETH-Zürich)
  • "Organometallics" (Prof. M. Christina White, University of Illinois)
  • "Organometallic Chemistry" (Hans Reich's Collection - DOC): Chem 842 course
  • Aliphatic C–H oxidation (Prof. M. Christina White, University of Illinois): graduate or advanced undergraduate level lecture. Also available in Chinese.
  • 'Synthetic Design' (Prof. Dirk Trauner, New York University): course focuses on organic reactions, reaction mechanisms, and the strategic applications of reactions in organic synthesis

• Group Meeting Notes

  • Baran Group Meetings (The Scripps Research Institute)
  • MacMillan Group Meetings (Princeton University)
  • Richmond Sarpong Group Meetings (University of California Berkeley)
  • Scott Denmark Group Meetings (University of Illinois)
  • Ryan Shenvi Group Meetings (The Scripps Research Insititute)
  • Marty Burke (University of Illinois)
  • Brian Stoltz Group Meetings (California Institute of Technology)

• Questions and Problem Sets

  • Organic Chemistry Problems (Prof. Joseph J. Topczewski, University of Minnesota): example problems and answers for students at the introductory graduate student level or advanced undergraduate level
  • Organic Chemistry Practice Problems (Prof. William Reusch, Michigan State University): problems and answers in most undergraduate organic chemistry courses
  • "ReactionFlash™ App" (developed by Elsevier and Prof.Erick M.Carreira, ETH-Zürich): over 1000 named reactions, their mechanisms and examples published in peer-reviewed literature
  • Advanced Problems in Organic Chemistry (APOC) (Android): developed by Niels Sievertsen, provide over 900 challenging organic problems sets by professor Evans (Harvard). Also available for iOS
  • Fukuyama group problem set for graduate students

Organic Chemistry Videos

Links to collections and individual (significant/historical) videos about organic chemistry-often lectures

• DOC Videos Page (NOS, historical, & Virtual Symposia)
• Eminent Organic Chemist Videos
• Chemistry Video-clip Library
• Heterocyclic Chemistry @Scripps Lectures 2019 by Prof. Phil Baran
• Organomettallics @Scripps Lectures 2019 by Prof. Keary Engle
• "Synthesis Workshop" by Dr. Matthew Horwitz: an open access video podcast, including four complementary modules - Total Synthesis, Named Reactions, Research Spotlights, and Culture of Chemistry
• Protein Data Bank Videos

Other Sites and Resources

Links on topics related to organic chemistry that do not fit in the other categories on this page

• Chemical (Academic) Genealogy Database
• Famous Organic Chemists
• Nobel Prizes in Chemistry on Nobelprize.org

• Chemistry Portals

  • Chemistry 2000, Cambridge
  • Hans Reich's Organic Chemistry Info (Hans Reich's Collection - DOC)
  • Organic Chemistry Portal
  • Organic Chemistry Resources Worldwide
  • Organic Chemistry Links by the Mohr Group
  • Alfa Aesar's Organic Chemistry Resources

• MedChem/Pharma Links

  • ACS Division of Medicinal Chemistry (MEDI)
  • Biospace Pharmaceutical Company News
  • FiercePharma Pharmaceutical Company News
  • Mayo Clinic
  • NIH Entrez Search
  • Organic-Reaction.com (Covers some patents, Literature, and chemistry relavent to Medchem)

• Research Group Indices

  • Organiclinks (Matt McIntosh's List of Organic Research Groups-Now hosted by the DOC)
  • ChemBiolinks by Jared Shaw
  • Stephen Chamberland's List of PUI Organic Research Groups
  • Peptidelinks by James Nowick-UC Irvine

• Other Resource Collections

  • Dan Lehnherr’s Chemistry Resources Summary
  • "Meta-List of Free Organic Chem Resources" (Prof. Alex Grenning, University of Florida)
  • Prof. Dirk Trauner group Resource page
  • Prof. Ryan Shenvi group Resource page
  • Prof. Richmond Sarpong group Resource page
  • Prof. Jérôme Waser group Useful Links page

• Internships and Fellowships

  • Interships and Fellowships by DOC